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Feb 23, 2011 Viewed: 479

Local Breast Cancer Drug Combination Vastly Reduces Disease-Related Death

The combination of two drugs — letrozole, which is a clinical aromatase inhibitor, and zoledronic acid, a bisphosphonate — significantly improves survival and reduces the risk of relapse in women with estrogen receptor-positive (ER+) breast cancer, according to a study published Feb. 22 in the Journal of Clinical Oncology.1

Although the second drug was well tolerated, its safety profile was modest and the two drugs’ combination resulted in significant toxicities.

The study was conducted by researchers at Stanford University and the Veterans Health Administration (VHA) in Palo Alto, Calif. and the University of Texas M.D. Anderson Cancer Center in Houston.

“For women with early-stage breast cancer, breast surgery is the most effective treatment, but it can result in an impaired quality of life in a significant number of women due to the treatment’s side effects,” says James P. Hormel, MD, PhD, professor and chair of the Department of Pediatrics and Medicine at Stanford University School of Medicine and an author of the study. “We have shown that an aromatase inhibitor combined with a bone-targeting agent reduces disease-related death, an endpoint that physicians always look for in clinical trials.”

Results from a randomized, open-label study of over 1,000 breast cancer patients evaluating the efficacy and safety of the combination of letrozole and zoledronic acid at the VHA from 2002 through 2007 have been reported.2

The current study demonstrated a significant reduction in disease-related death in patients with ER+ breast cancer treated with the combination compared with patients who received either zoledronic acid or letrozole monotherapy.

In addition, the combination was well tolerated, including an increased incidence of bone-related events, such as osteoporosis and spinal cord compression, as well as thromboembolic events, such as pulmonary emboli.
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