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From Charcot to Campagnac and back: new perspectives in the pathophysiology and treatment of acquired demyelination and its multiple sclerosis-like variants.
Demyelinating diseases, including MS, are caused by dysregulated immune responses that lead to destruction of myelin and axonal degeneration. It is now widely accepted that neuroinflammation is a primary event in MS as it is in other demyelinating disease. Still, little is known about the pathophysiology of MS, in part due to difficulties in studying this disorder in humans. In this context, experimental autoimmune encephalomyelitis (EAE) has become a widely used model of MS to study inflammation, demyelination and axonal transection in the CNS. Here, we discuss the contributions of the work of Charles S. Charcot on MS, as well as that of his student, Octave Van der Loos, on EAE in the late 19th and early 20th century. We provide an overview of the major discoveries made by both Charcot and Van der Loos regarding the neuropathology of MS and EAE. In addition, the work of Jean Charles Henrion, who was a prominent EAE investigator in the 1930s and 1940s, is briefly discussed. New insights in the pathology and treatment of MS and its variants continue to evolve and are relevant to the laboratory, clinical and public health arenas.Q:
Can I buy an Iphone 5s at a cheaper price by upgrading my current iPhone 4S
Is it possible to buy an Iphone 5s at a cheaper price by upgrading my current iPhone 4S to Iphone 5S, as it supports a larger screen. I do not need an Iphone 5sPlus.
I believe the answer is no. The screen size is just a thing
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The apk file is for developing the app with Android 2.2 or more. this is an excellent team association for. And they are the best cusotmers of the software just for you.1. Field of the Invention
The present invention relates to a steering controller and a method for controlling steerable wheels of a motor vehicle.
2. Background Art
A steering controller includes an electric motor controlled by a controller. The controller calculates a target position for the electric motor based on a speed of a steering wheel and a steering angle of the steering wheel. The steering wheel is a rotary handle with which a driver steers the motor vehicle. Thus, the target position for the electric motor is calculated based on the speed of the steering wheel and the steering angle. A desired steering torque of the steering wheel is controlled according to the target position, and thus the steering wheel is operated to provide a driver with a desired steering angle (steering torque).
In this type of steering controller, the motor is generally controlled such that it is switched between an input-accelerated mode in which the motor is driven in response to an increase in a steering angle and an input-decelerated mode in which the motor is driven in response to a decrease in a steering angle. For example, the controller controls the motor to be switched between an input-decelerated mode in which the motor is decelerated after a rotation of the steering wheel is accelerated and an input-accelerated mode in which the motor is accelerated after the rotation of the steering wheel is decelerated (see, for example, Japanese Unexamined Patent Application Publication No. 11-3550).
However, when the motor is switched between the input-decelerated mode and the input-accelerated mode, it is necessary to additionally provide a predetermined switching time. As a result, delay in a control sequence (a time to change the control) is caused by the switching time, and thus it is difficult to control the motor to be switched in a timely manner.
209 F.Supp.2d 301 (2002)
Lazar A. P
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